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In addition to MIFs immunogenic role, it has also been claimed to Enjoy a vital function throughout neural embryonic improvement. Shen et al. (2013) shown which the MIF pathway is needed for that survival of statoacoustic ganglia and sensory hair cells within a zebrafish model. Using knockdown with antisense oligonucleotide morpholinos (MOs) and/or
MIF is required for the conversation involving NLRP3 plus the intermediate filament protein vimentin, that's significant for NLRP3 activation. more, we reveal that MIF interacts with NLRP3, indicating a role for MIF in inflammasome activation impartial of its purpose for a cytokine. These details advance our understanding of how MIF regulates infla